NF-Y protein chain A {alpha} (CAAT-box DNA-binding protein subunit A, CCAAT-binding transcription factor subunit B, CBF-B, NFYA)

Function

• component of nuclear factor V
• stimulates the transcription of various genes by recognizing & binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin & beta-actin genes
• NF-YB & NF-YC must interact & dimerize for NF-YA association & DNA binding

Structure

belongs to the NFYA/HAP2 subunit family

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• protein subunit

Component of

• nuclear factor Y; CAAT-box DNA-binding protein; CCAAT-binding transcription factor; CBF, (NFY)

Database

• UniProt: http://www.uniprot.org/uniprot/P23511.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4800
• OMIM: https://mirror.omim.org/entry/116897
• OMIM: https://mirror.omim.org/entry/189903