POU domain, class 6, transcription factor 1; brain-specific homeobox/POU domain protein 5; brain-5; Brn-5; mPOU homeobox protein (POU6F1, BRN5, MPOU, TCFB1)

Function

• transcription factor
• binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (putative)

Structure

• belongs to the POU transcription factor family, class-6 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

nucleus

Expression

• in the embryo, expressed exclusively in the developing brain
• in the adult, expression is restricted to brain, heart, skeletal muscle & lung
• in the brain, highest expression in specific cell layers of the cerebral cortex, the olfactory bulb, the hippocampus & the cerebellum

More general terms

• homeobox protein
• POU protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5463
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5463
• UniProt: http://www.uniprot.org/uniprot/Q14863.html