6-phosphofructo-1-kinase, phosphohexokinase or phosphofructokinase-1

Function

• carbohydrate degradation, glycolysis
• D-glyceraldehyde 3- phosphate & glycerone phosphate from D-glucose: step 3/4

ATP + D-fructose 6-phosphate -> ADP + D-fructose 1,6-bisphosphate

Cofactor: Mg+2

Structure

• tetramer
• muscle is M4, liver is L4, & red cell is M3L, M2L2, or ML3
• in humans PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) & PFKP (platelet)

More general terms

• phosphofructokinase

More specific terms

• 6-phosphofructokinase X
• liver 6-phosphofructokinase; phosphofructokinase 1; phosphohexokinase; phosphofructo-1-kinase isozyme B; PFK-B (PFKL)
• muscle 6-phosphofructokinase (phosphofructokinase 1, phosphohexokinase, phosphofructo-1-kinase isozyme A, PFK-A, phosphofructokinase-M, PFKM, PFKX)
• platelet 6-phosphofructokinase (phosphofructokinase 1, phosphohexokinase, phosphofructo-1-kinase isozyme C, PFK-C, 6-phosphofructokinase platelet type, PFKP, PFKF)