liver 6-phosphofructokinase; phosphofructokinase 1; phosphohexokinase; phosphofructo-1-kinase isozyme B; PFK-B (PFKL)

Function

• 6-phosphofructokinase in liver
• carbohydrate degradation, glycolysis
• D-glyceraldehyde 3- phosphate & glycerone phosphate from D-glucose: step 3/4
• allosteric enzyme activated by ADP, AMP, or fructose bisphosphate & inhibited by ATP or citrate

Cofactor: Mg+2

Structure

• tetramer
  • belongs to the phosphofructokinase family, two domains subfamily

Alternative splicing

named isoforms=2

More general terms

• 6-phosphofructokinase

Database

• UniProt: http://www.uniprot.org/uniprot/P17858.html
• OMIM: https://mirror.omim.org/entry/171860