muscle 6-phosphofructokinase (phosphofructokinase 1, phosphohexokinase, phosphofructo-1-kinase isozyme A, PFK-A, phosphofructokinase-M, PFKM, PFKX)

Function

• 6-phosphofructokinase in muscle
• carbohydrate degradation, glycolysis
• D-glyceraldehyde 3-phosphate & glycerone phosphate from D-glucose: step 3/4
• allosteric enzyme activated by ADP, AMP, or fructose bisphosphate & inhibited by ATP or citrate

Cofactor: Mg+2

Structure

• tetramer
• belongs to the phosphofructokinase family, two domains subfamily

Alternative splicing

named isoforms=2

Pathology

defects in PFKM are the cause of glycogen storage disease type 7

More general terms

• 6-phosphofructokinase

Database

• UniProt: http://www.uniprot.org/uniprot/P08237.html
• OMIM: https://mirror.omim.org/entry/232800