platelet 6-phosphofructokinase (phosphofructokinase 1, phosphohexokinase, phosphofructo-1-kinase isozyme C, PFK-C, 6-phosphofructokinase platelet type, PFKP, PFKF)

Function

• 6 phosphofructokinase is a tetramer in muscle is M4, liver is L4, & red cell is M3L,M2L2, or ML3
• a subunit composition with a higher proportion of platelet type subunits is found in platelets, brain & fibroblasts
• carbohydrate degradation, glycolysis
• D-glyceraldehyde 3-phosphate & glycerone phosphate from D-glucose: step 3/4
• allosteric enzyme activated by ADP, AMP, or fructose bisphosphate & inhibited by ATP or citrate

Cofactor: Mg+2

Structure

• tetramer
• belongs to the phosphofructokinase family, 2 domains subfamily

More general terms

• 6-phosphofructokinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q01813.html
• OMIM: https://mirror.omim.org/entry/171840