ankyrin repeat & SOCS box protein 9; ASB-9 (ASB9)

Function

• substrate-recognition component of an elongin-Cullin-SOCS-box protein (ECS) E3 ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• recognizes at least two forms of creatine kinase, CKB & CKMT1A
• protein modification; protein ubiquitination

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (putative)
• contains 6 ANK repeats
• contains 1 SOCS box domain

Compartment

mitochondria

Alternative splicing

• named isoforms=3
• isoform 2 or 3 does not interact with the elongin BC complex; likely to be a negative regulator of isoform 1

Expression

• predominantly expressed in testis, kidney, & liver

More general terms

• Ankyrin repeat & SOCS box protein (ASB)

Additional terms

• Notch/ankyrin repeat
• SOCS box domain

Component of

• ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=140462
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:140462
• UniProt: http://www.uniprot.org/uniprot/Q96DX5.html