ubiquitous/mitochondrial creatine kinase (U-mtCK, CKMT1, CKMT1A, CKMT, CKMT1B, Mia-CK)

Function

• reversibly catalyzes transfer of phosphate between ATP & various phosphogens (e.g. creatine phosphate)
• creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain & spermatozoa
• mitochondrial creatine kinase binds cardiolipin

ATP + creatine <--> ADP + phosphocreatine

Structure

• octamer composed of four MTCK homodimers
• belongs to the ATP:guanido phosphotransferase family

Compartment

• mitochondrial inner membrane intermembrane side

More general terms

• creatine kinase

Database

• UniProt: http://www.uniprot.org/uniprot/P12532.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1159
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5485
• OMIM: https://mirror.omim.org/entry/123290