rab6a proto-oncogene protein; Ras-related protein Rab-6A; Rab-6 (RAB6A, RAB6)
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Function
- retrograde GOLGI-ER & intra-GOLGI traffic
- motility of GOLGI-ER vesiclesFunction: protein transport
- has a low GTPase activity
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with SCYL1BP1
- interacts with VSP52 & RABGAP1.
- isoform 1 interacts with RAB6KIFL; isoform 2 does not
- isoforms 1 & 2 interact with BICD1 & BICD2
Structure
Compartment
Golgi apparatus membrane; lipid-anchor
Alternative splicing
named isoforms=2
Expression
More general terms
Additional terms
- kinesin-like protein KIF20A (rabkinesin-6, rab6-interacting kinesin- like protein, GG10-2, KIF20A, RAB6KIFL)
- rab6 GTPase-activating protein (rab6-GAP) or GYP6
References
- ↑ UniProt http://www.uniprot.org/uniprot/P20340.html
- ↑ Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M. Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. Nature. 1991 Apr 25;350(6320):715-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1902553
- ↑ Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11796263
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5870