Rab GTPase-activating protein 1 (Rab6 GTPase-activating protein GAPCenA, GAP & centrosome-associated protein, RABGAP1)

Function

• may act as a GTPase-activating protein of RAB6A
• may play a role in microtubule nucleation by centrosome
• may participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition
• interacts with RAB6A & tubulin gamma

Structure

• contains 1 PID domain
• contains 1 Rab-GAP TBC domain

Compartment

• cytoplasm, centrosome
• predominantly cytosolic but also associated with centrosome

Alternative splicing

named isoforms=4

More general terms

• rab GTPase-activating protein (rab-GAP)
• centrosomal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y3P9.html