protein bicaudal D homolog 2 (Bic-D 2, BICD2, KIAA0699)

Function

• may play a role in the dynein-dynactin interactions on the surface of membranous organelles
• regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (putative)
• interacts with DCTN2 & RAB6A (putative)
• interacts with NEK9
• phosphorylated by NEK9 in vitro

Structure

• belongs to the BicD family
• 4th coiled coil region is involved in Golgi targeting & in the interaction with DCTN2 (putative)

Compartment

• Golgi, cytoplasm, cytoskeleton
• in interphase cells mainly localizes to the Golgi, colocalizes with dynactin at microtubule plus ends
• its localization is dependent on microtubule morphology

Alternative splicing

named isoforms=2 (due to intron retention)

Expression

ubiquitous

More general terms

• phosphoprotein
• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TD16.html