sterol O-acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2; ACAT-2; cholesterol acyltransferase 2 (SOAT2, ACACT2, ACAT2)

Function

• plays a role in lipoprotein assembly & dietary cholesterol absorption
• in addition to its acyltransferase activity, it may act as a ligase
• may provide cholesteryl esters for lipoprotein secretion from hepatocytes & intestinal mucosa
• may form homo- or heterodimers (putative)

acyl-CoA + cholesterol = CoA + cholesterol ester

Structure

• belongs to the membrane-bound acyltransferase family sterol o-acyltransferase subfamily

Compartment

• endoplasmic reticulum membrane; multi-pass membrane protein

More general terms

• cholesterol acyltransferase
• transmembrane 8 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8435
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8435
• OMIM: https://mirror.omim.org/entry/601311
• UniProt: http://www.uniprot.org/uniprot/O75908.html