sphingosine-1-phosphate phosphatase 2; SPPase2; Spp2; hSPP2; sphingosine-1-phosphatase 2 (SGPP2)

Function

• phosphatase for
  • dihydrosphingosine-1-phosphate
  • sphingosine-1-phosphate
• role in attenuating intracellular sphingosine 1-phosphate signaling (putative)
• role in pro-inflammatory signaling (putative)

Structure

• belongs to the type 2 lipid phosphate phosphatase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• expressedin kidney & heart > brain, colon, small intestine & lung
• not expressed in skeletal muscle, thymus, spleen, liver, placenta, & peripheral blood leukocytes
• strongly induced by TNF
• also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, & other cell types
• not induced by growth-related factors

More general terms

• phosphomonoesterase
• transmembrane 8 protein

Additional terms

• sphingosine-1-phosphate phosphatase 1; SPPase1; Spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1 (SGPP1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=130367
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:130367
• OMIM: https://mirror.omim.org/entry/612827
• UniProt: http://www.uniprot.org/uniprot/Q8IWX5.html