sphingosine-1-phosphate phosphatase 1; SPPase1; Spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1 (SGPP1)

Function

• enzymatic activity with both sphingosine 1-phosphate & dihydro-sphingosine 1-phosphate
• regulates intracellular & extracellular concentrations of sphingosine 1-phosphate

Structure

• belongs to the type 2 lipid phosphate phosphatase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein

Expression

• ubiquitous
• highest expression in placenta & kidney

More general terms

• phosphomonoesterase
• transmembrane 9 protein

Additional terms

• sphingosine-1-phosphate phosphatase 2; SPPase2; Spp2; hSPP2; sphingosine-1-phosphatase 2 (SGPP2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81537
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81537
• OMIM: https://mirror.omim.org/entry/612826
• UniProt: http://www.uniprot.org/uniprot/Q9BX95.html