mucin-17 (MUC-17, small intestinal mucin-3, MUC-3, MUC17, MUC3)

Function

• probably plays a role in maintaining homeostasis on mucosal surfaces
• interacts via its C-terminus with PDZK1 & this interaction appears important for proper localization
• probably cleaved within the SEA domain

Structure

• N-glycosylated, not O-glycosylated
• contains high mannose & complex-type glycans
• contains 1 EGF-like domain
• contains 1 SEA domain

Compartment

• membrane
• forms containing the complex type glycans localize to the cell surface
• isoform 2: secreted (probable)

Alternative splicing

named isoforms=2

Expression

• expressed almost exclusively in the intestine
• expression is especially high in both the duodenum & transverse colon
• expressed in mature absorptive cells of the small intestinal villi
• no expression is detected in goblet cells

Pathology

• highly expressed in pancreatic adenocarcinoma tissue (at protein level)
• expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers

More general terms

• mucin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=140453
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1404
• OMIM: https://mirror.omim.org/entry/608424
• UniProt: http://www.uniprot.org/uniprot/Q685J3.html