CDw210a; interleukin-10 (IL-10) receptor alpha chain; IL-10R-A; IL-10R1 (IL10RA IL10R)

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Function

along with IL10RB forms receptor for IL10
binds IL10 with a high affinity

Structure

belongs to the type II cytokine receptor family

Compartment

membrane

Expression

expressed in spleen, thymus, & PBMC
weak expression in pancreas, skeletal muscle, brain, heart, & kidney
placenta, lung, & liver show intermediate levels
monocytes, B-cells, large granular lymphocytes, & T-cells express high levels

Pathology

defects in IL10RA found in infantile-onset Crohn's disease

More general terms

Component of

interleukin-10 receptor (IL10 receptor)

References

↑ UniProt http://www.uniprot.org/uniprot/Q13651.html
↑ SeattleSNPs http://pga.gs.washington.edu/data/il10ra/
↑ Glocker E-O et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009 Nov 19; 361:2033 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19890111
Kelsall B. Interleukin-10 in inflammatory bowel disease. N Engl J Med 2009 Nov 19; 361:2091. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19890110

Database

Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3587
OMIM: https://mirror.omim.org/entry/146933
UniProt: http://www.uniprot.org/uniprot/Q13651.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3587

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