PHD finger protein 11; BRCA1 C-terminus-associated protein; renal carcinoma antigen NY-REN-34 (PHF11 BCAP)

Function

• positive regulator of Th1-type cytokine gene expression
• interacts with BRCA1 & RELA

Structure

contains 1 PHD-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• highly expressed in T-cells & B-cells
• also expressed in NK cells & mature dendritic cells
• expressed at higher levels in Th1 cells as compared to Th2 cells
• expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver & placenta

Polymorphism

• variation in PHF11 seems to be associated with a propensity to childhood atopic dermatitis & asthma

More general terms

• PHD finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51131
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51131
• OMIM: https://mirror.omim.org/entry/147050
• OMIM: https://mirror.omim.org/entry/607796
• UniProt: http://www.uniprot.org/uniprot/Q9UIL8.html