PR domain zinc finger protein 7; histone-lysine N-methyltransferase PRDM7; PR domain-containing protein 7 (PRDM7, PFM4)

Function

• histone methyltransferase (putative)

S-adenosyl-L-methionine + L-lysine-[[[A137031|histone]]] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[[[A137031|histone]]]

Structure

• contains 1 KRAB-related domain
• contains 1 SET domain

Compartment

• nucleus (putative)
• chromosome

Alternative splicing

• named isoforms=3
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Comparative biology

• the mouse orthologous protein seems not to exist according to
• human PRDM7 & PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human & mouse

More general terms

• histone N-methyltransferase
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11105
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11105
• OMIM: https://mirror.omim.org/entry/609759
• UniProt: http://www.uniprot.org/uniprot/Q9NQW5.html