PR domain zinc finger protein 9; histone-lysine N-methyltransferase PRDM9; PR domain-containing protein 9 (PRDM9, PFM6)

Function

• histone methyltransferase
• specifically trimethylates Lys-4 of histone H3 during meiotic prophase & is essential for proper meiotic progression
• does not have the ability to mono- & dimethylate Lys-4 of histone H3
• H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation
• role in transcriptional activation of genes during early meiotic prophase

S-adenosyl-L-methionine + L-lysine-[[[A137031|histone]]] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[[[A137031|histone]]]

Structure

• contains 14 C2H2-type Zn+2 fingers
• contains 1 KRAB-related domain
• contains 1 SET domain

Compartment

• nucleus (putative)
• chromosome

More general terms

• histone N-methyltransferase
• C2H2 type zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56979
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56979
• OMIM: https://mirror.omim.org/entry/609760
• UniProt: http://www.uniprot.org/uniprot/Q9NQV7.html