zinc finger protein 350; zinc-finger protein ZBRK1; zinc finger & BRCA1-interacting protein with a KRAB domain 1; KRAB zinc finger protein (ZNF350, ZFQR, ZBRK1)

Function

• transcriptional repressor
• binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3
• interacts with BRCA1
• associated with nuclear matrix

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 8 C2H2-type zinc fingers
• contains 1 KRAB domain

Compartment

nucleus, nuclear matrix

Expression

widely expressed

More general terms

• C2H2 type zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59348
• OMIM: https://mirror.omim.org/entry/605422
• UniProt: http://www.uniprot.org/uniprot/Q9GZX5.html