peroxisomal proliferator-activated receptor A-interacting complex 285 kD protein; ATP-dependent helicase PRIC285; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PDIP1; PPAR-gamma DBD-interacting protein 1 (PRIC285, KIAA1769, HELZ2)

Function

• helicase
• transcriptional coactivator for nuclear receptors including
  • PPARA, PPARG, THRA, THRB, RXRA
• interacts with PPARA, ESR1, THRB, RXRA, PPARG
• component of PPAR alpha-interacting complex (PRIC)
• interacts with the DNA-binding domain of PPARG

Structure

• contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs
  • these motifs are not required for interaction with PPARG
• belongs to the DNA2/NAM7 helicase family
• contains 1 C2H2-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood, placenta

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• receptor
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85441
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85441
• OMIM: https://mirror.omim.org/entry/611265
• UniProt: http://www.uniprot.org/uniprot/Q9BYK8.html