F-box/LRR-repeat protein 5; F-box & leucine-rich repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like protein (FBXL5 FBL4 FBL5 FLR1)

Function

• recognizes & binds to phosphorylated proteins & promotes their ubiquitination & degradation (putative)
• interacts with SKP1
• component of SKP1-cullin-F-box protein ligase complex (SCF complex) that plays a role in iron homeostasis by promoting ubiquitination & subsequent degradation of IREB2/IRP2
• with high iron & oxygen level, it specifically recognizes & binds IREB2/IRP2, promoting its ubiquitination & degradation by the proteasome
• promotes ubiquitination & subsequent degradation of DCTN1/p150-glued protein modification
• ubiquitinated upon iron & oxygen depletion, leading to its degradation by the proteasome
• ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen & iron sensor
• interacts with ACO1/IRP1, IREB2/IRP2; the interaction depends on the 4Fe-4S cluster
• interacts with DCTN1/p150-glued

Structure

• the hemerythrin-like region acts as an oxygen & iron sensor by binding oxygen through a diiron metal-center; in absence of oxygen & iron, the protein is ubiquitinated & degraded
• contains 1 F-box domain
• contains 4 LRR repeats (leucine-rich repeats)

Compartment

cytoplasm, perinuclear region

Alternative splicing

named isoforms=2

More general terms

• F-box & leucine-rich repeat protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26234
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26234
• OMIM: https://mirror.omim.org/entry/605655
• UniProt: http://www.uniprot.org/uniprot/Q9UKA1.html