iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2; IRP2 (IREB2)

Function

• binds to iron-responsive elements
  • binding to the IRE element in ferritin mRNA results in repression of translation
  • binding to transferrin receptor mRNA inhibits degradation of this otherwise rapidly degraded mRNA

Cofactor: binds 1 4Fe-4S cluster per subunit (putative)

Structure

belongs to the aconitase/IPM isomerase family

Compartment

cytoplasm

More general terms

• iron-responsive element [IRE]-binding protein

Additional terms

• iron response element

Database

• OMIM: https://mirror.omim.org/entry/147582
• UniProt: http://www.uniprot.org/uniprot/P48200.html