iron-responsive element [IRE]-binding protein

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Introduction

Requires free sulfyhydryl group(s) for activity. Fe+2 may promote oxidation of IRE-BP & decreased affinity for IRE.

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References

  1. Hentze MW et al Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 244:357 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2711187
  2. Klausner RD & Harford JB cis-trans models for post-transcriptional gene regulation. Science 246:870 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2683086

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