iron-responsive element [IRE]-binding protein
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Introduction
Requires free sulfyhydryl group(s) for activity. Fe+2 may promote oxidation of IRE-BP & decreased affinity for IRE.
More general terms
More specific terms
- cytoplasmic aconitate hydratase; aconitase; citrate hydro-lyase; iron-responsive element-binding protein 1; IRE-BP 1; iron regulatory protein 1; IRP1; ferritin repressor protein (ACO1, IREB1)
- iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2; IRP2 (IREB2)
Additional terms
References
- ↑ Hentze MW et al Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 244:357 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2711187
- ↑ Klausner RD & Harford JB cis-trans models for post-transcriptional gene regulation. Science 246:870 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2683086