ubiquitin carboxyl-terminal hydrolase 20; deubiquitinating enzyme 20; ubiquitin thiolesterase 20; ubiquitin-specific-processing protease 20; VHL-interacting deubiquitinating enzyme 2; hVDU2 (USP20, KIAA1003, LSFR3A, VDU2)

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Function

deubiquitinating enzyme
role in beta-2 adrenergic receptor (ADRB2) recycling
acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating deubiquitination of ADRB2
role in ADRB2 recycling & resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 & inhibiting lysosomal trafficking of ADRB2
upon dissociation, probably transferred to translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination & disengagement from ADRB2
this suggests the existence of a dynamic exchange between ADRB2 & beta-arrestins
deubiquitinates DIO2, thereby regulating thyroid hormones
deubiquitinates HIF1A, leading to stabilize HIF1A & enhance HIF1A-mediated activity
mediates deubiquitination of both Lys-48- & Lys-63- linked polyubiquitin chains
thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
ubiquitinated via a VHL-dependent pathway for proteasomal degradation
interacts with VHL, leading to its ubiquitination & subsequent degradation
interacts with DIO2 & HIF1A

the UBP-type Zn+2 finger binds 3 Zn+2
it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (putative)
belongs to the peptidase C19 family, USP20/USP33 subfamily
contains 2 DUSP domains
contains 1 UBP-type Zn+2 finger