somatostatin receptor 1; SS1R; SRIF-2 (SSTR1)

Function

• receptor for somatostatin
• higher affinity for somatostatin-14 than somatostatin-28
• coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
• additionally, stimulates phosphotyrosine phosphatase & Na+/H+ exchanger via pertussis toxin insensitive G proteins
• interacts with SKB1

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• fetal kidney, fetal liver
• adult pancreas, brain, lung, jejunum & stomach

More general terms

• somatostatin receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6751
• OMIM: https://mirror.omim.org/entry/182451
• UniProt: http://www.uniprot.org/uniprot/P30872.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6751