neuropeptide Y receptor type 2; NPY2-R; NPY-Y2 receptor; Y2 receptor (NPY2R)

Function

• receptor for neuropeptide Y & peptide YY
• rank order of affinity for pancreatic polypeptides is: PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY & NPY free acid

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane; multi-pass membrane protein

Expression

• high levels in amygdala, corpus callosum, hippocampus & subthalamic nucleus
• also detectable in caudate nucleus, hypothalamus & substantia nigra
• vagal Npy2r(+) neurons largely co-express Trpv1 & respond to capsaicin

More general terms

• neuropeptide Y receptor

Additional terms

• neuropeptide Y; Proneuropeptide Y contains: neuropeptide Y; neuropeptide tyrosine; NPY; C-flanking peptide of NPY; CPON (NPY)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4887
• OMIM: https://mirror.omim.org/entry/162642
• UniProt: http://www.uniprot.org/uniprot/P49146.html