neuropeptide Y receptor type 2; NPY2-R; NPY-Y2 receptor; Y2 receptor (NPY2R)
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Function
- receptor for neuropeptide Y & peptide YY
- rank order of affinity for pancreatic polypeptides is: PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY & NPY free acid
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
cell membrane; multi-pass membrane protein
Expression
- high levels in amygdala, corpus callosum, hippocampus & subthalamic nucleus
- also detectable in caudate nucleus, hypothalamus & substantia nigra