angiotensin II receptor type-1 (AGTR1, AT1, AT1AR, AT1BR, AGTR1A, AGTR1B, AT2R1, AT2R1B)
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Function
- receptor for angiotensin II
- G protein-coupled receptor, activates a phosphatidylinositol- Ca+2 2nd messenger system
- C-terminal Ser or Thr may be phosphorylated
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Expression
- expressed in liver, lung, adrenal, adrenocortical adenomas
Pathology
- defects in AGTR1 are a cause of renal tubular dysgenesis
Polymorphism
- AGTR1 gene polymorphisms associated with hypertension
- two polymorphisms in AGTR1 promoter, in complete linkage disequilibrium are associated with human longevity[6]
More general terms
Additional terms
- angiotensin II (Giapreza)
- type-1 angiotensin 2 receptor-associated protein (AT1 receptor-associated protein, AGTRAP, ATRAP)
References
- ↑ UniProt http://www.uniprot.org/uniprot/P30556.html
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=AGTR1
- ↑ SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=AGTR1
- ↑ Wikipedia; Note: angiotensin receptor entry http://en.wikipedia.org/wiki/angiotensin_receptor
- ↑ 6.0 6.1 Benigni A et al Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. Age (Dordr). 2012 May 9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22569962