type-1 angiotensin 2 receptor-associated protein (AT1 receptor-associated protein, AGTRAP, ATRAP)

Function

• negative regulator of angiotensin 2 receptor 1-mediated signaling by regulating receptor internalisation & receptor desensitization, i.e. phosphorylation
• inhibits cell proliferation
• inhibits angiotensin 2-stimulated transcriptional activity
• interacts with GNB2L1/RACK1, & with the C-terminal region of AGTR1

Compartment

• endoplasmic reticulum membrane, Golgi membrane, cytoplasmic cytoplasmic vesicle membrane, perinuclear vesicular membrane, endocytic vesicle

Alternative splicing

named isoforms=2

Expression

• ubiquitous but more abundant in kidney, heart, pancreas, thyroid

More general terms

• transmembrane 3 protein

Additional terms

• angiotensin II receptor type-1 (AGTR1, AT1, AT1AR, AT1BR, AGTR1A, AGTR1B, AT2R1, AT2R1B)

Database

• OMIM: https://mirror.omim.org/entry/608729
• UniProt: http://www.uniprot.org/uniprot/Q6RW13.html