centaurin-gamma-3; Arf-GAP with GTPase, ANK repeat & PH domain-containing protein 3; AGAP-3; CRAM-associated GTPase; CRAG; Cnt-g3; MR1-interacting protein; MRIP-1 (AGAP3, CENTG3)

Function

• GTPase-activating protein for the ADP ribosylation factor family (putative)
• GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway
• GTPase activity is stimulated by oxidative stress
• interacts with PML
• interacts with expanded polyglutamine proteins

Structure

• belongs to the centaurin gamma-like family
• contains 3 ANK repeats
• contains 1 Arf-GAP domain
• contains 1 PH domain

Compartment

• cytoplasm
• in cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies

Alternative splicing

named isoforms=4

Expression

widely expressed

More general terms

• centaurin gamma
• phosphoprotein
• ankyrin repeat domain protein (ANKRD)

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116988
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:116988
• UniProt: http://www.uniprot.org/uniprot/Q96P47.html