POU domain, class 2, transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; octamer-binding protein 2; Oct-2; octamer-binding transcription factor 2; OTF-2 (POU2F2, OCT2, OTF2)

Function

• transcription factor & DNA-binding protein
• specifically binds to the octamer motif 5'-ATTTGCAT-3'
• regulates transcription in a number of tissues
• activates immunoglobulin gene expression
• modulates transcription transactivation by NR3C1, AR & PGR
• isoform 5 activates the U2 small nuclear RNA (snRNA) promoter
• interacts with NR3C1, AR & PGR

Structure

• belongs to the POU transcription factor family, class- 2 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

• cytoplasm (putative)
• nucleus

Alternative splicing

named isoforms=5

Expression

• isoform 3 is B-cell specific
• isoform 5 is expressed in B-cells & the immunoglobulin- expressing T-cell line molt-4, but not in the T-cell line BW 5147

More general terms

• octamer transcription factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5452
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5452
• OMIM: https://mirror.omim.org/entry/164176
• UniProt: http://www.uniprot.org/uniprot/P09086.html