claudin-7; CLDN-7 (CLDN7 CEPTRL2 CPETRL2)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space (putative)
• directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3 (putative)

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein

Alternative splicing

• named isoforms=2

Expression

• expressed in kidney, lung & prostate
• isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form
• induced by androgens

Pathology

• down-regulated in breast cancers, including
  • ductal carcinoma in situ (DCIS)
  • lobular carcinoma in situ (LCIS
  • invasive ductal carcinoma (IDC) (at protein level)
• down-regulated in several cancer cell lines
• loss of expression correlates with histological grade, with diminished expression predominantly in high-grade lesions

More general terms

• claudin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1366
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1366
• OMIM: https://mirror.omim.org/entry/609131
• UniProt: http://www.uniprot.org/uniprot/O95471.html