claudin-2; SP82 (CLDN2)
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Function
- plays a major role in tight junction-specific obliteration of the intercellular space, through Ca+2-independent cell-adhesion activity (putative)
- can form homo- & heteropolymers with other CLDN homopolymers
- interacts with CLDN3, but not CLDN1, homopolymers
- directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3
Structure
- belongs to the claudin family
Compartment
- cell junction, tight junction
- cell membrane; multi-pass membrane protein
Pathology
- defects may be associated with chronic pancreatitis[2]
Comparative biology
- may serve as a novel biomarker for pre-diabetes in mice[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P57739.html
- ↑ Jump up to: 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
- ↑ Jump up to: 3.0 3.1 Songtao Y, Fangyu L, Jie C, Li Y. Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes. Front Pharmacol. 2024 Feb 15;15:1370708. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38425650 PMCID: PMC10902111 Free PMC article.