claudin-2; SP82 (CLDN2)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space, through Ca+2-independent cell-adhesion activity (putative)
• can form homo- & heteropolymers with other CLDN homopolymers
• interacts with CLDN3, but not CLDN1, homopolymers
• directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein

Pathology

• defects may be associated with chronic pancreatitis

Comparative biology

• may serve as a novel biomarker for pre-diabetes in mice

More general terms

• claudin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9075
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9075
• OMIM: https://mirror.omim.org/entry/300520
• UniProt: http://www.uniprot.org/uniprot/P57739.html