claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE-receptor 2; CPE-R 2; rat ventral prostate.1 protein homolog; hRVP1 (CLDN3 C7orf1 CPETR2)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space, through Ca+2-independent cell-adhesion activity (putative)
• can form homo- & heteropolymers with other CLDN homopolymers
• interacts with CLDN1 & CLDN2 homopolymers
• directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3 (putative)

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein

More general terms

• claudin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1365
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1365
• OMIM: https://mirror.omim.org/entry/602910
• UniProt: http://www.uniprot.org/uniprot/O15551.html