3'(2'),5'-bisphosphate nucleotidase 1; bisphosphate 3'-nucleotidase 1; PAP-inositol-1,4-phosphatase; PIP (BPNT1)

Function

• converts adenosine-3'-phosphate-5'-phosphosulfate (PAPS) to adenosine-5'-phosphosulfate (APS)
• converts 3'(2')-phosphoadenosine-5'-phosphate (PAP) to AMP
• 1000-fold lower activity towards inositol-1,4-bisphosphate (ins(1,4)P2) & inositol-1,3,4-trisphosphate (ins(1,3,4)P3), but does not hydrolyze ins(1)P, ins(3,4)P2, ins(1,3,4,5)P4 or insP6

Cofactor: Mg+2

Inhitition:

• uncompetitive inhibition by micromolar concentrations of Li+

Structure

belongs to the inositol monophosphatase family

Alternative splicing

named isoforms=2

Expression

• highly expressed in kidney, liver, pancreas & heart
• detected at lower levels in brain, placenta, lung & skeletal muscle

More general terms

• nucleotidase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10380
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10380
• OMIM: https://mirror.omim.org/entry/604053
• UniProt: http://www.uniprot.org/uniprot/O95861.html