cAMP-specific 3',5'-cyclic phosphodiesterase 4D; DPDE3; PDE43 (PDE4D, DPDE3)

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Function

,adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate ,

Cofactor:

Inhibition:

  • inhibited by rolipram.

Structure

Compartment

Alternative splicing

Expression

Polymorphism

  • genetic variations in PDE4D might (or might not) be associated with susceptibility to stroke[3]

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q08499.html
  2. Galoyan AA, Gurvitz BYa, Sharova NP. Cyclic nucleotide phosphodiesterase and 5'-nucleotidase: a coupled system. Neurochem Res. 1989 Dec;14(12):1213-21. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2560820
  3. 3.0 3.1 Rosand J et al Many hypotheses but no replication for the association between PDE4D and stroke. Nat Genet. 2003 Oct;35(2):131-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17006457
  4. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5144

Database