three prime repair exonuclease 2; 3'-5' exonuclease TREX2; 26S proteasome-associated UCH37-interacting protein 1 (TREX2)

Function

• exonuclease with a preference for dsDNA with mismatched 3' termini
• may play a role in DNA repair
• exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates

Cofactor:

• Mg+2, required for activity
• substitution with Mn+2 results in partial activity

Kinetic parameters:

• pH dependence: optimum pH is 7.5-8.0

Structure

• homodimer
• belongs to the exonuclease superfamily, TREX family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach & thymus

Genetics

• the gene for UIP1 is either identical to or adjacent to that of TREX2
• most mRNAs that encode UIP1 also include the N-terminal part of TREX2

More general terms

• exodeoxyribonuclease
• nuclear protein

Additional terms

• HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769 (HAUS7, UCHL5IP, UIP1)
• three prime repair exonuclease 2; 3'-5' exonuclease TREX2; 26S proteasome-associated UCH37-interacting protein 1 (TREX2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11219
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11219
• OMIM: https://mirror.omim.org/entry/300370
• UniProt: http://www.uniprot.org/uniprot/Q9BQ50.html