HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769 (HAUS7, UCHL5IP, UIP1)

Function

• contributes to mitotic spindle assembly, maintenance of centrosome integrity & completion of cytokinesis as part of the HAUS augmin-like complex
• binds UCHL5

Structure

belongs to the HAUS7 family

Compartment

• cytoplasm, cytoskeleton, centrosome, spindle
• localizes to interphase centrosomes & to mitotic spindle microtubules

Alternative splicing

named isoforms=3

Expression

• detected in spleen, thymus, testis, ovary, small intestine & colon
• highest expression in testis & ovary

Genetics

• the gene for this protein is either identical to or adjacent to that of TREX2
• most mRNAs that encode UCHL5IP alsoinclude the N-terminal part of TREX2

Notes

• uncertain whether Met-1 or Met-11 is the initiator

More general terms

• phosphoprotein
• protein subunit

Additional terms

• three prime repair exonuclease 2; 3'-5' exonuclease TREX2; 26S proteasome-associated UCH37-interacting protein 1 (TREX2)

Component of

• HAUS augmin-like complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55559
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55559
• OMIM: https://mirror.omim.org/entry/300540
• UniProt: http://www.uniprot.org/uniprot/Q99871.html