ubiquitin thiolesterase L5; ubiquitin C-terminal hydrolase L5; UCH-L5 (UCHL5, UCH37, CGI-70, AD-019)

Function

• deubiquitinating enzyme associated with proteasome component of the 19S (PA700) regulatory complex of the 26S proteasome
• interacts with ADRM1, activated by ADRM1
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

belongs to the peptidase C12 family

Alternative splicing

named isoforms=4

More general terms

• ubiquitin C-terminal hydrolase

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Component of

• 26S proteasome

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y5K5.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5137