DNA-damage-inducible transcript 4-like protein (protein regulated in development & DNA damage response 2, REDD-2, HIF-1 responsive protein RTP801-like, DDIT4L, REDD2 RTP801L)

Function

• inhibits cell growth by regulating the FRAP1 pathway
• upstream of the TSC1-TSC2 complex & downstream of AKT1

Structure

belongs to the DDIT4 family

Compartment

cytoplasm (putative)

Expression

• up-regulated in atherosclerotic plaques relative to healthy segments of the same artery
• up-regulated by oxidized LDL & hypoxia in macrophages

More general terms

• uncharacterized protein

Database

• OMIM: https://mirror.omim.org/entry/607730
• UniProt: http://www.uniprot.org/uniprot/Q96D03.html