thymopoietin alpha; lamina-associated polypeptide 2, isoform alpha; TP alpha; thymopoietin-related peptide isoform alpha; TPRP isoform alpha; contains: thymopoietin; TP; splenin; TP5 (TMPO, LAP2)

Function

• may be involved in the structural organization of the nucleus & in the post-mitotic nuclear assembly
• may play a role, together with LMNA, in nuclear anchorage of RB1
• TP & TP5 may play a role in T-cell development & function
• TP5 is an immunomodulating pentapeptide
• phosphorylated in a mitose-specific manner
• interacts with LMNA, BANF1 & RB1 & with chromosomes
• associates with lamins at specific cell-cycle stages

Structure

• the N-terminal part contains two structurally independent, non-interacting domains:
  • LEM-like (also called LAP2-N or LEM-D)
    • LEM-like binds DNA while
  • LEM (also called LAP2-C or LEM-B).
    • LEM interacts with BANF1
• the C-terminal domain forms a four-stranded coiled coil
• belongs to the LEM family
• contains 1 LEM domain
• contains 1 LEM-like domain

Compartment

• nucleus. chromosome
• expressed diffusely throughout the nucleus

Alternative splicing

• named isoforms=3; alpha, beta, gamma
• additional isoforms seem to exist

Expression

• expressed in many tissues
• most abundant in adult thymus & fetal liver

Pathology

• defects in TMPO are the cause of dilated cardiomyopathy type 1T

Pharmacology

• TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) & Mepentil (Recordati)
• used in treatment of primary & secondary immune deficiencies, autoimmunity, infections & cancer

More general terms

• thymopoietin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7112
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7112
• OMIM: https://mirror.omim.org/entry/188380
• OMIM: https://mirror.omim.org/entry/613740
• UniProt: http://www.uniprot.org/uniprot/P42166.html