Sheehan's syndrome

Etiology

• pituitary apoplexy in the setting of complicated labor & delivery.
• generally associated with obstetric hemorrhage & hypotension

Clinical manifestations

• failure of post-partum lactation
• amenorrhea, failure to resume menses
• increasing fatigue & cold intolerance
• acute adrenal insufficiency
  • hypotension NOT responsive to volume replacement & pressors

Laboratory

• see hypopitutarism & adrenal insufficiency

Radiology

• CT or MRI to view the sella turcica

Complications

• central adrenal insufficiency is the primary cause of mortality
• secondary hypothyroidism

Management

• hydrocortisone

More general terms

• pituitary apoplexy
• syndrome
• pregnancy disorder; obstetric disorder; pregnancy complication