post-polio syndrome

^[1]^[2]^[3]^[4]^[5]^[6]

Introduction

Progressive muscle weakness developing 20-30 years after poliomyelitis.

dysfunction of surviving motor neurons
slow disintegration of axon terminals
late denervation of muscles
reactivation of latent or persistent poliovirus in the central nervous system may occur in some patients

mild to moderate deterioration in function
fatigue
muscle pain
fasciculations
muscle weakness
onset is gradual
manifestations may stabilize or progress to muscle atrophy
extremities are often affected
respiratory muscle &/or bulbar involvement
- severe dysphagia
- choking
- aspiration
- sleep apnea

↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 823, 1236
↑ M. Wasaka, St. Mary's Medical Center
↑ ^3.0 ^3.1 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
↑ ^4.0 ^4.1 Koopman FS, Uegaki K, Gilhus NE et al Treatment for postpolio syndrome. Cochrane Database Syst Rev. 2011 Feb 16;(2):CD007818. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21328301
Koopman FS, Beelen A, Gilhus NE et al. Treatment for postpolio syndrome. Cochrane Database Syst Rev. 2015;(5):CD007818 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25984923 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007818.pub3/full
↑ ^5.0 ^5.1 Huang YH, Chen HC, Huang KW et al Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis. BMC Neurol. 2015 Mar 22;15:39. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25886512 PMCID: PMC4379590 Free PMC article.
↑ National Institute of Neurological Disorders and Stroke (NINDS) Post-Polio Syndrome https://catalog.ninds.nih.gov/pubstatic//12-4030/12-4030.pdf