forkhead box A (FOXA)
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Introduction
The forkhead box A family of transription factors are human homologous of PHA-4 of C elegans, linked to the longevity effects of calorie restriction in worms.
Function
- roles in development
- regulation of glucagon production & glucose homeostasis in adults, especially in response to fasting
More general terms
More specific terms
- forkhead box protein A1; hepatocyte nuclear factor 3-alpha; HNF-3A (FOXA1)
- forkhead box protein A2; hepatocyte nuclear factor 3-beta; HNF-3B (FOXA2)
References
- ↑ Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007 May 2; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/17476212