forkhead box protein A1; hepatocyte nuclear factor 3-alpha; HNF-3A (FOXA1)

Function

• transcription factor for liver genes, including albumin AFP, tyrosine aminotransferase, PEPCK
• interacts with cis-acting regulatory regions of these genes Strucuture: contains 1 fork-head DNA-binding domain

Compartment

nucleus

Expression

• expressed in tissues of endodermal origin, i.e., stomach, intestines, liver, lung

Pathology

• gene amplification in esophageal adenocarcinoma & lung cancer

More general terms

• forkhead family transcription factor
• phosphoprotein
• hepatocyte nuclear factor

Database

• OMIM: https://mirror.omim.org/entry/602294
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3169
• UniProt: http://www.uniprot.org/uniprot/P55317.html