phosphoenolpyruvate carboxykinase

Introduction

An enzyme obtained from Escherichia coli, yeast, & Trypanosoma brucei contains a putative ATP-binding site, presumably using ATP instead of GTP, but is NOT related to this form. In eukaryotes there are two isozymes: a cytoplasmic one (PEPCK1) & a mitochondrial one (PEPCK2)

More general terms

• kinase or ATP-phosphotransferase
• carboxy-lyase or decarboxylase
• gluconeogenic enzyme

More specific terms

• phosphoenolpyruvate carboxykinase 1 (PCK1, cytosolic phosphoenolpyruvate carboxykinase)
• phosphoenolpyruvate carboxykinase 2 (mitochondrial phosphoenolpyruvate carboxykinase, PEPCK-M, PCK2, PEPCK2)

Additional terms

• gluconeogenesis