Trypanosoma brucei (African trypanosomiasis)
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Epidemiology
- Africa
- infect both animals & humans
- transmitted by the bite of the tsetse fly (genus Glossina)
Clinical manifestations
(also see T. brucei-rhodesiense & T. brucei-gambiense)
Laboratory
- diagnosis is made by demonstrating parasites in thick & thin films of peripheral blood, buffy coat, lymph node or bone marrow aspirates or biopsies or spun CSF stained with Giemsa
- trypomastigotes in blood (image[3])
- multi-curved
- measure up to 30 um in length
- small kinetoplast
- Trypanosoma brucei antibody in serum
- Trypanosoma brucei gambiense Ab in serum
- Trypanosoma brucei rhodesiense Ab in serum
- high levels of IgM in blood & CSF
- CSF pleocytosis 50-500 mononuclear cells/uL
- Trypanosoma brucei DNA[4]
- culture or animal innoculation
- elevated serum transaminases (case report)[3]
More general terms
More specific terms
- Trypanosoma brucei-brucei
- Trypanosoma brucei-gambiense (African sleeping sickness)
- Trypanosoma brucei-rhodesiense
Additional terms
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1266
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1193-96
- ↑ 3.0 3.1 3.2 Sun LH (image) Medical detectives raced to save a man from a rare 'universally lethal' disease. Washington Post. Dec 22, 2016
- ↑ 4.0 4.1 Loinc
- ↑ Centers for Disease Control & Prevention (CDC) African Trypanosomiasis (African Sleeping Sickness) https://wwwnc.cdc.gov/travel/diseases/african-sleeping-sickness-african-trypansosomiasis