phosphoenolpyruvate carboxykinase 1 (PCK1, cytosolic phosphoenolpyruvate carboxykinase)

Function

• carbohydrate biosynthesis; gluconeogenesis
• activity is affected by a number of hormones regulating gluconeogenesis (including glucagon, insulin, glucocorticoids)

GTP + oxaloacetate <--> GDP + phosphoenolpyruvate + CO2

Structure

• belongs to the phosphoenolpyruvate carboxykinase [GTP] family

Compartment

cytoplasm

Expression

• major sites of expression are liver, kidney & adipocytes

More general terms

• phosphoenolpyruvate carboxykinase

Database

• UniProt: http://www.uniprot.org/uniprot/P35558.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5105
• OMIM: https://mirror.omim.org/entry/261680
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5105