staphylococcal nuclease domain-containing protein 1 (p100 co-activator, 100 kD coactivator, EBNA2 coactivator p100, SND1)

Function

• bridging factor between STAT6 & basal transcription facto
• role in PIM1 regulation of MYB
  • phosphorylated by PIM1 in vitro
• transcriptional coactivator for EBV nuclear antigen 2 (EBNA2)
• binds to acidic transactivation domain of EBNA2
• interacts with EAV NSP1, STAT5, GTF2E1 & GTF2E2
• forms ternary complex with STAT6 & POLR2A

Structure

• contains 4 TNase-like domains
• contains 1 Tudor domain

Compartment

• cytoplasm, nucleus
• in IL-4 stimulated cells colocalizes with STAT6 in nucleus

Expression

ubiquitously expressed

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602181
• UniProt: http://www.uniprot.org/uniprot/Q7KZF4.html