myosin heavy chain 11; myosin-11; myosin heavy chain, smooth muscle isoform; SMMHC (MYH11, KIAA0866)

Function

• muscle contraction
• myosin heavy chain

Structure

• myosin is a hexameric protein that consists of
  • 2 myosin heavy chain subunits
  • 2 myosin essential light chain subunits
  • 2 myosin regulatory light chain subunits
• each myosin heavy chain can be split into 1 light meromyosin & 1 heavy meromyosin; it can later be split further into 2 globular subfragments (S1) & 1 rod-shaped subfragment (S2)
• rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
• contains 1 IQ domain
• contains 1 myosin head-like domain

Compartment

• melanosome
• smooth muscle

Expression

• expressed in the umbilical artery, bladder, esophagus & trachea

Pathology

• pericentric chromosomal inversion inv(16)(p13;q22) involving MYH11 is found in AML-M4 EO subtype; the inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) & the tail region of MYH11
• defects in MYH11 are the cause of aortic aneurysm familial thoracic type 4

More general terms

• myosin heavy chain

Additional terms

• myosin

Database

• UniProt: http://www.uniprot.org/uniprot/P35749.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4629
• OMIM: https://mirror.omim.org/entry/132900
• OMIM: https://mirror.omim.org/entry/160745
• UniProt: http://www.uniprot.org/uniprot/P35749.html